With Denoiser, we were able to crank up the ISO to 12800. With the a7R III, a much better low-light camera, we were able to push it up to ISO 6400 with minimal noise without Denoiser. The 5D Mark IV is not a good low-light camera, but with Denoiser III, instead of having a maximum ISO of 1600 before noise became an issue, we were able remove noise all the way up to ISO 6400. When applying Denoiser III to Sony a7RIII and Canon 5D Mark IV footage, they both benefited.
As we stated before, with Denoiser III, you can gain up to three more stops without having to worry about noise.